Normocin™ is the first innovative formulation active against Gram+ & Gram– bacteria, mycoplasmas and fungi. Indeed current commercial antimicrobial agents display selective action against either mycoplasma or Gram +, Gram– bacteria and/or fungi .

Normocin™ displays a very broad antimicrobial activity spectrum through three compounds:

• Two of them are antibiotics active against both Gram+, Gram– bacteria and mycoplasmas: one acts by binding to the 50S subunit of ribosomes halting bacterial protein synthesis and the other acts by interfering with bacterial DNA synthesis.
• The third compound is an anti-fungal agent which eradicates yeasts and some filamentous fungi by disrupting ionic exchange through the fungal cell membrane.

These different targets of Normocin are completely absent in mammalian cells.

Normocin is truly bactericidal and not simply bacteriostatic. The two antibiotic compounds present a broader antibacterial activity spectrum than penicillin/streptomycin mixture.

Normocin can be added to penicillin/streptomycin preparation to expand the activity spectrum of this mixture especially against mycoplasmas and fungi :

• Normocin prevents mycoplasmal cell contamination by killing extracellular mycoplasmas.
• The anti-fungal agent in Normocin presents the same mechanism of action than amphotericin B while being more stable and less toxic.

Therefore Normocin™ is the preventive solution against microbial contamination of cell cultures.